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    For example, they maintain ejection fraction, cardiac contractility, and cardiac output in severe hypoxia.

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    These data demonstrate that a lower level of EDNRB significantly improves cardiac performance and tissue perfusion under various levels of hypoxia. Functions related to these gene networks were consistent with a better cardiac contractility and performance.

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    The significance of single Parkin mutations in the pathogenesis of PD is debated. To assess olfaction results according to Parkin mutation status. To compare the prevalence of Parkin single heterozygous mutations in patients diagnosed with PD to the rate in healthy controls in order to establish whether these single mutations could be a risk factor for developing PD. Parkin gene mutation testing was performed in young onset PD diagnosed heterozygote mutation carriers, Parkin single heterozygote mutation carriers, and non-carriers of Parkin mutations.

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    Of young onset PD cases tested, 8 2. Olfaction results were available in cases eight compound heterozygotes, nine single heterozygotes, and non-carriers.

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    Patients with Parkin compound heterozygous mutations have relatively preserved olfaction compared to Parkin single heterozygotes and non-carriers. The prevalence of Parkin single heterozygosity is similar to the 3.

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